How and why minimal residual disease studies are necessary in leukemia: a review from WP10 and WP12 of the European LeukaemiaNet.

How and why minimal residual disease studies are necessary in leukemia: a review from WP10 & WP12 of the European LeukaemiaNet

Acknowledgments: we are grateful to members of the WP12 and WP10 of the European LeukemiaNet initiative for their support and critical review of the manuscript, Drs. G. Basso (Padua), P. Bettelheim (Vienna), D. Grimwade (London), W. Kern (Munich), F. Lanza (Ferrara), A. Porwit (Stockholm), A. Rawstron (Leeds), S. Richards (Leeds), G. Saglio (Turin), G. Schuurhuis (Rotterdam), T. Te Kronnie (Pad...

The relation between end of induction minimal residual disease and different risk factors in patients with acute lymphoblastic leukemia

Background: Malignant disorder with B or T stem cell basis leads to development and continuation of acute lymphoblastic leukemia (ALL) due to aggregation of blast cells in bone marrow. The environmental, genetic, and demographic factors may influence the disease relapse. The objective of this study was to assess the relation between end of induction minimal residual disease and different risk f...

Evaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR

Effective Dendritic Cell-based Immunotherapeutic Vaccines for Acute Myeloid Leukemia (AML)

Acute myeloid leukemia (AML) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. Leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (MRDs) which are resistant to current chemotherapeutic regimens and mediate disease relapse. Current therapeutic vaccine strategies have d...

Healthcare and Compassion: Towards an Awareness of Intersubjective Vulnerability; Comment on “Why and How Is Compassion Necessary to Provide Good Quality Healthcare?”

How to instill compassion in a healthcare organization? In this article, I respond to Marianna Fotaki’s proposals in her piece, ‘Why and how is compassion necessary to provide good quality healthcare?’ by drawing on insights from organization studies. Following Fotaki, I argue that to instill targets and formal measures for assessing compassion would be problematic. I conclude by drawing on psy...